https://www.cainolab.org/contact daily 0.75 2024-03-16 https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/1efca01c-de96-4b9e-89e3-09fe071be2f4/Untitled239.JPEG Contact https://www.cainolab.org/lab-news daily 0.75 2025-12-10 https://www.cainolab.org/lab-pubs daily 0.75 2024-12-26 https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/1e2e9fa2-3adf-46af-8229-56e142857133/MCR2022.jpg Pubs - -AACR Editor’s pick- Furnish M; Boulton DP; Genther V; Grofova D; Ellinwood ML; Romero L; Lucia MS; Cramer SD; Caino MC. “MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling”. Mol Cancer Res 2022 Apr 1;20(4):607-621. doi: 10.1158/1541-7786.MCR-21-0374. In this manuscript, we identify a novel crosstalk between mitochondria and the integrated stress response in prostate cancer. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/8b57faa9-5bbb-4391-8fc1-48deed99e36d/Boulton+et+al+2022.png Pubs - Boulton DP, Caino MC. “Mitochondrial Fission and Fusion in Tumor Progression to Metastasis”. Front. Cell Dev. Biol., 09 March 2022 | https://doi.org/10.3389/fcell.2022.849962. In this review, we discuss emerging evidence linking mitochondrial fragmentation with tumor progression to metastasis. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/ff237d6a-8d1b-4b16-9bce-36ea97b225b7/CR2024.png Pubs - Boulton DP, Hughes CP, Vaira V, Del Gobbo A, Palleschi A, Locatelli M, Danis E, Raza M, Neumann AJ, Purdy SP, Lerma R, Meshki J, Ford HL, Prekeris R, Morrissey C, Caino MC. “MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity”. Cell Reports , 2024, published online ahead of print. https://www.sciencedirect.com/science/article/pii/S2211124724014712. In this manuscript, we show that that knockdown of MIRO2 ubiquitously reduces tumor cell invasion in vitro and suppresses metastatic burden in prostate and breast cancer mouse models. Mechanistically, depletion of MIRO2’s binding partner—unconventional myosin 9B (MYO9B)— reduces tumor cell invasion and phenocopies MIRO2 depletion; which in turn results in increased active RhoA. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/6921dc35-99f6-4bb7-95c9-8bad56de72f1/Furnish+et+al+2029.png Pubs - -Top cited article from Cancer Reports- Furnish M, Caino MC. “Altered mitochondrial trafficking as a novel mechanism of cancer metastasis”.Cancer Rep (Hoboken) . 2020 Feb;3(1):e1157. doi: 10.1002/cnr2.1157. In this review, we discuss emerging evidence that implicates exacerbated mitochondrial movement as a contributor to metastatic potential of cancer cells. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/18df64b3-133b-40ac-becb-fe1c89dd8dad/Dillon+JBC+2024.jpg Pubs - Boulton DP, Caino MC. “Emerging roles for Mitochondrial Rho GTPases in tumor biology”. J Biol Chemistry , September 2024; 300:9. https://doi.org/10.1016/j.jbc.2024.107670. In this review, we summarize evidence that MIRO1 and MIRO2 are important regulators of tumor cell biology. https://www.cainolab.org/research daily 1.0 2025-12-10 https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/90ca1d75-29f0-4b6d-84da-30a501b9f169/mito+dynamics+updated+%28Figure+1%29+second+revision.png Research - Mitochondrial dynamics in cancer. A key mechanism by which tumors regulate mitochondrial functions are the collective processes of mitochondrial dynamics. Mitochondrial dynamics refers to spatiotemporal regulation of gross morphology, transport of organelles, inner membrane and cristae morphology, communication between adjacent mitochondria and contact with other organelles such as the endoplasmic reticulum. Current projects look into the functional consequences of mitochondrial shape changes in the metastatic potential of cancer cells. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/54ccc0b3-4b78-4e44-ae08-9972b508e920/mito+trafficking+%282%29.png Research - Deregulated mitochondrial trafficking fuels metastasis. Syntaphilin (SNPH), the molecular brake anchoring mitochondria to microtubules, is broadly expressed in normal tissues and lost in most cancer types, including breast cancer. Higher levels of SNPH were associated with removal of mitochondria from the cortical cytoskeleton, impaired focal adhesion dynamics and inhibition of tumor cell invasion and metastasis. In patients, SNPH loss in tumors correlated with shortened patient survival. Current projects examine how SNPH is regulated in metastatic cancer, with the long term goal of exploiting this knowledge for therapeutic gain. https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/ea0577fe-c276-4e4c-a3c0-b6e277e7e68c/Picture2.png Research - Mitochondria engage the integrated stress response to stimulate metastatic cancer growth. Our work identified a novel signaling pathway that drives the growth of prostate cancer. This pathway is centered in Mitochondrial Rho GTPase 2 (MIRO2), a small GTPase of the Ras superfamily. MIRO2 binding to GCN1 led to activation of the integrated stress response kinase GCN2, facilitating translation of ATF4, both in vitro and in vivo. MIRO2 is overexpressed in metastatic cancers and higher levels of MIRO2 correlate with poor patient survival. Current projects aim to test the value of MIRO2/GCN1/GCN2 as therapeutic targets in metastatic cancer. https://www.cainolab.org/lab-fun daily 0.75 2023-11-21 https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/5c7f1b58-7ac8-4170-ba55-0aaf6d0b5454/Ray+ASCB+25.JPEG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/57b8c76a-bca2-48f5-8d3e-550982219a06/IMG_7023.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/982737cd-1be4-43b3-a598-162c14ddab8d/IMG_7703.JPG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/3e28a6d5-f632-4ba7-974b-11d92ded807f/IMG_7621.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/45b4a5fc-dde8-4fb6-9e6d-2a5663419a02/IMG_6922.PNG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/c1bb8f30-2dd9-46e2-a130-5f2298bfa041/IMG_5829.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/3f77802b-0fc9-4b1a-8182-7f621ee81ee5/IMG_6340.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/7886545e-bbd0-4bc8-b729-ffeb5ce4b51b/Lab+June+2025.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/67770d0a-7efd-473f-a5f8-cb206c133ca2/ceci+reyland+prize.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/7310f895-7d42-4a2e-be04-062ac6c203db/IMG_2306.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/519969ec-a956-436d-928c-1c5440747ef9/Rianna+poster+capitol+2025.JPEG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/52ca30e8-2050-4413-846c-099faa67c3ba/IMG_5595.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/c0cd82c1-8e78-4f73-82d8-5285457b37e5/IMG_5323.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/5b39a1dc-ccd7-49f8-a853-942732a613ac/IMG_5322.jpg Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/169aeff3-ea0b-4e34-a529-f3995b9c52da/Ceciaward2024.jpg Pictures Ceci won a Faculty Excellence in Teaching award from the Department of Pharmacology https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/d2540d84-9506-40ae-bba6-958b70627118/IMG_5393.PNG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/5e157cd2-3af4-45d8-aed7-9288a1fac36c/IMG_5392.PNG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/0261fa03-fb0c-4f14-919c-88b0d5898473/Reina+ABRACMS.jpeg Pictures Reina with her poster at ABRACMS 2024 - she won a presentation award in the Cancer Biology section. Congrats! https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/e1b7bcd0-3070-4f15-ad65-624ad1370014/Raymundo+SACNAS.jpg Pictures Raymundo at the SACNAS NDiSTEM conference, as a panelist translating resilience into success https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/726cae4e-50b8-4f29-af23-2076bcd03a53/IMG_5384.PNG Pictures https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/466802cf-9c0a-4e96-b35c-a69791fb0112/6-DillonB.jpeg Pictures Dillon's image won 1st place on the Pharm Art contest https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/433443e2-daa8-4eeb-9fd6-8e756d1cf826/mitobackground.jpg Pictures Ceci's epoxy resin 3D art on "Diversity of mitochondria cristae" https://images.squarespace-cdn.com/content/v1/622d428b86940a7d7dc06482/32fe3ba7-7e3a-4149-88b2-fe570685c4d3/Cancer_pharmacology.png Pictures 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